标题:Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction
作者:Dong, SZ[1];Lei, YB[1];Jia, SK[1];Gao, LX[2];Li, J[2];Zhu, T[1];Liu, SY[1];Hu, WH[1]
作者全称:Dong, Suzhen[1];Lei, Yubing[1];Jia, Shikun[1];Gao, Lixin[2];Li, Jia[2];Zhu, Tong[1];Liu, Shunying[1];Hu, Wenhao[1]
通讯作者地址:Liu, SY; Hu, WH (reprint author), East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Sch Chem & Mol Engn, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China.
出版年:2017
卷:27
期:4
页码:1105-1108
关键词:New structure; Oxindole; Polycycle; PTP1B inhibitor; Spirotetrahydrofurochroman
摘要:Protein tyrosine phosphatase 1B (PTP1B) has been proposed to be an ideal target for treatment of type II diabetes and obesity. However, no druggable P 更多
收录类别:SCOPUS;SCIE;PubMed
当年影响因子:2.454
5年影响因子:2.222
JCR分区:Q3
资源类型:外文期刊论文
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